DNA as the Genetic Material: Classical Experiments that Transformed Modern Biology

An academic overview of the key twentieth-century experiments that established DNA, and in some viruses RNA, as the molecular basis of heredity.

BIOTECHNOLOGY

Dr. Mainak Mukhopadhyay

11/26/2025

Griffith's experiment discovering the "transforming principle" in Streptococcus pneumoniae (pneumococcal) bacteria.

The Avery-MacLeod-McCarty experiment (1944) demonstrated that DNA is the substance that carries genetic information, not protein.

The Hershey and Chase experiment was a 1952 study that proved DNA is the genetic material, not protein

Fraenkel Conrat experiment was based on the evidences that RNA also carry the genetic information and also responsible for the viral reconstitution.